Biological Risk Management Methodology defines biological risk management, which includes the assessment and organization of measures to reduce biological risks. Biological risk assessment is an element of the biological risk management system is a set of organizational, analytical and practical measures aimed at preventing the occurrence of negative consequences of exposure to hazardous biological factors, means, methods, technologies, services in various fields of activity related to the treatment with pathogenic biological agents. Handling of pathogenic biological agents shall be intended processes (stages) of work with pathogenic biological agents, directly aimed at the isolation (detection), development (creation), production (manufacturing), circulation (including import (export), storage, transportation) of pathogenic biological agents for the purpose of their research, destruction and (or) development of immunobiological drugs. Pathogenic biological agent shall be intended microorganisms, poisons of biological and plant origin (toxins), helminths, nematodes that can cause an infectious and (or) parasitic process in the body of a person, animal or plants. Biological risks are divided into four levels: (a) low level of biological risk - an environmental situation resulting from a natural disaster, major accident or catastrophe, destruction of a potentially dangerous biological object, capable of causing infectious and (or) parasitic diseases of humans, animals and plants and not spreading from an infected organism to a healthy one, for which effective means and methods of treatment and prevention are available, including vaccines; (b) medium level of biological risk - the environmental situation that has developed in as a result of a natural disaster, a major accident or catastrophe, the destruction of a potentially dangerous biological object that can cause infectious and (or) parasitic diseases of humans, animals and plants with minimal spread from an infected organism to a healthy one or easily spread from an infected organism to a healthy one, for which effective means and methods of treatment and prevention are available, including vaccines; (c) high level of biological risk - an environmental situation resulting from a natural disaster, major accident or catastrophe, destruction of a potentially dangerous biological object, capable of causing infectious and (or) parasitic diseases of humans, animals and plants that easily spread from an infected organism to a healthy one, including for which there are no vaccines or effective treatments; and (d) acceptable level of biological risk - a state in which low, medium and high levels of biological risks are excluded in the context of the emergence of environmental situations of a natural and man-made nature, the use of modern weapons by the enemy with the provision of security measures to protect the population and the protection of individual components of the natural environment from the effects of hazardous biological factors.