Methodical Instruction for determination of the level of natural resistance and valuation of immune status of fishes (No.13-4-2/1795 of 1999). Country/Territory Russian Federation Document type Regulation Date 1999 Source FAO, FAOLEX Subject Fisheries Keyword Fish disease Freshwater fishes Marine fishes Research Animal health Geographical area Arctic, Asia and the Pacific, Black Sea, Caspian Sea, CIS (Commonwealth of Independent States), Eastern Europe, Europe, Europe and Central Asia, North Pacific, North-West Pacific Entry into force notes Entry into force from the date of issue. Abstract Natural resistance of fishes is innate capacity of the organism to resist aggressive impact of pathogenic factors of biotic and a biotic nature, including pathogens of infectious and invasion disease and product of their vital activity (exo- and endo-toxins). Immune status is structural and functional state of immune system at the concrete stage of life cycle of species. The document consists of 4 Secs. Section 1 lays down general provisions. Section 2 classifies unspecific factors of immunity. Depending upon structural organization of unspecific factors of immunity their components are sub-divided into cellular and humeral. Section 3 regards specific immune system. Specific immune system consists of cellular and humeral components. They differ from unspecific factors by specificity of inter-action with alien agents. Section 4 regards determination of tensity of immunity. Tensity of immunity is intended capacity of organism of fishes to resist aggressive impact of pathogens and their products of metabolism and disintegration (exo- and endo-toxins). Full text Russian